RETICULOCYTE ASSESSMENT AS A BIOMARKER FOR BONE MARROW ERYTHROPOIETIC FUNCTION IN PREGNANT WOMEN ATTENDING ANTENATAL CLINIC IN BENIN CITY, NIGERIA.
Keywords:Biomarkers, Reticulocyte production index, Micronutrients, Erythropoiesis.
A decrease in iron stores in pregnancy is accompanied by a significant rise in the reticulocyte count .This study was aimed at using reticulocyte production index as a biomarker for erythropoietic function in pregnant women. Packed cell volume was determined using sysmex Automated Hematology System. Reticulocyte count was determined using the supra vital staining techniques. It was observed that there was a significant decrease in packed cell volume at stage 4 when compared to stage 1, 2 or 3, (P < 0.05) and significant increase in reticulocyte count , reticulocyte index and reticulocyte production index at stage 4 when compared to stage 1, 2 or 3 (P < 0.05). The significant decrease in packed cell volume coupled with an increase in Reticulocyte production index is a reflection of an increased erythropoiesis activity of the bone marrow, occasioned by the increased fetal demand for micro-nutrients which is associated with pregnancy. Proper compliance to vitamin B12, folic acid and iron supplementations are advocated during pregnancy.
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